Raif S Geha Selected Research

Wiskott-Aldrich Syndrome

10/2016	A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.
11/2015	Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia.
10/2015	Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells.
3/2012	B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice.
4/2011	A peptide derived from the Wiskott-Aldrich syndrome (WAS) protein-interacting protein (WIP) restores WAS protein level and actin cytoskeleton reorganization in lymphocytes from patients with WAS mutations that disrupt WIP binding.
5/2009	WIP is critical for T cell responsiveness to IL-2.
12/2008	Primary immune deficiencies with aberrant IgE production.
4/2006	A second-site mutation in the initiation codon of WAS (WASP) results in expansion of subsets of lymphocytes in an Wiskott-Aldrich syndrome patient.
2/2006	WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha.
12/2005	Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome.

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Raif S Geha Research Topics

Disease

37	Inflammation (Inflammations) 01/2022 - 01/2002
25	Atopic Dermatitis (Atopic Eczema) 01/2022 - 09/2003
12	Wiskott-Aldrich Syndrome 10/2016 - 08/2002
11	Infections 01/2022 - 08/2003
8	Eosinophilia 01/2022 - 10/2003
8	Common Variable Immunodeficiency 12/2018 - 06/2007
7	Food Hypersensitivity (Food Allergy) 01/2019 - 06/2011
6	Colitis 11/2020 - 12/2008
6	Ectodermal Dysplasia (Aplasia Cutis Congenita) 01/2018 - 09/2004
6	Hypersensitivity (Allergy) 08/2015 - 01/2002
5	Virus Diseases (Viral Diseases) 01/2021 - 03/2013
5	Lymphopenia (Lymphocytopenia) 01/2020 - 08/2003
5	Primary Immunodeficiency Diseases 08/2014 - 08/2002
4	Contact Dermatitis (Eczema, Contact) 01/2021 - 09/2010
4	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2020 - 12/2008
4	Neoplasms (Cancer) 01/2019 - 08/2004
4	Respiratory Hypersensitivity 01/2019 - 03/2002
3	Staphylococcal Infections 11/2021 - 10/2016
3	Bacterial Infections (Bacterial Infection) 10/2019 - 11/2010
3	Asthma (Bronchial Asthma) 01/2019 - 09/2003
3	Skin Diseases (Skin Disease) 01/2018 - 08/2004
3	Reinfection 11/2017 - 12/2014
3	Eczema 11/2017 - 12/2015
3	Lymphoma (Lymphomas) 10/2017 - 09/2013
3	Job Syndrome (Hyper-IgE Syndrome) 11/2016 - 12/2008
3	Agammaglobulinemia (Hypogammaglobulinemia) 01/2016 - 08/2003
3	Kaposi Varicelliform Eruption (Eczema Herpeticum) 12/2015 - 12/2007
2	COVID-19 01/2021 - 01/2020
2	Cytopenia 01/2021 - 07/2019
2	Chronic Granulomatous Disease 11/2020 - 10/2017
2	Vasculitis (Vasculitides) 01/2020 - 01/2019
2	Hyperplasia 01/2020 - 01/2016
2	Autoimmune Hemolytic Anemia (Cold Agglutinin Disease) 07/2019 - 11/2017
2	Dysbiosis 01/2019 - 11/2016
2	Pruritus (Itching) 01/2019 - 01/2009
2	Diarrhea 11/2017 - 01/2016
2	Anaphylaxis (Anaphylactic Shock) 11/2016 - 02/2013
2	Thrombocytopenia 1 11/2015 - 04/2011
2	Respiratory Tract Infections (Respiratory Tract Infection) 08/2015 - 08/2014
2	Dermatitis 02/2014 - 10/2003
2	Parasitic Diseases (Parasitic Disease) 12/2008 - 09/2003
2	DiGeorge Syndrome (Syndrome, DiGeorge) 12/2008 - 02/2006
2	Inborn Genetic Diseases (Disease, Hereditary) 10/2003 - 04/2002
1	Reticular dysgenesis 01/2020

Drug/Important Bio-Agent (IBA)

24	AntigensIBA 01/2022 - 03/2002
15	Immunoglobulin E (IgE)IBA 01/2022 - 01/2002
14	Proteins (Proteins, Gene)FDA Link 10/2017 - 08/2002
13	CytokinesIBA 01/2018 - 03/2002
11	AllergensIBA 11/2020 - 01/2002
10	OvalbuminIBA 10/2020 - 01/2002
9	LigandsIBA 12/2018 - 06/2007
7	Immunoglobulin G (IgG)IBA 08/2014 - 01/2002
6	Interleukin-17 (Interleukin 17)IBA 01/2019 - 10/2007
6	CalciumIBA 01/2016 - 10/2007
5	Intravenous Immunoglobulins (IVIG)FDA Link 01/2021 - 04/2003
5	Filaggrin ProteinsIBA 01/2019 - 09/2009
5	Cyclophilins (Cyclophilin)IBA 07/2011 - 10/2007
5	NF-kappa B (NF-kB)IBA 12/2008 - 10/2003
4	Interleukin-4 (Interleukin 4)IBA 11/2021 - 10/2009
4	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 11/2020 - 12/2008
4	Messenger RNA (mRNA)IBA 01/2019 - 06/2006
4	Immunoglobulin M (IgM)IBA 10/2017 - 04/2004
3	HaptensIBA 09/2021 - 05/2009
3	Interleukin-13IBA 01/2021 - 10/2009
3	EnzymesIBA 01/2020 - 10/2012
3	ChemokinesIBA 01/2020 - 07/2014
3	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2019 - 12/2005
3	AntibodiesIBA 01/2019 - 09/2003
3	Interleukin-22 (IL-22)IBA 01/2019 - 01/2016
3	Wiskott-Aldrich Syndrome ProteinIBA 01/2018 - 12/2003
3	Interleukin-33IBA 11/2017 - 01/2016
3	AutoantibodiesIBA 10/2017 - 11/2015
3	Immunoglobulin A (IgA)IBA 10/2017 - 04/2004
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 01/2019
2	Complement System Proteins (Complement)IBA 01/2021 - 10/2007
2	Interleukin-18 (Interleukin 18)IBA 01/2021 - 11/2017
2	SaltsIBA 11/2020 - 07/2014
2	Dextran SulfateIBA 11/2020 - 07/2014
2	Nonsense Codon (Nonsense Mutation)IBA 11/2017 - 01/2015
2	VaccinesIBA 10/2017 - 10/2003
2	MitogensIBA 10/2017 - 03/2016
2	Thymic Stromal LymphopoietinIBA 01/2016 - 08/2008
2	InterferonsIBA 12/2015 - 06/2015
2	I-kappa B KinaseIBA 07/2010 - 10/2007
2	Interleukin-2 (IL2)IBA 12/2005 - 06/2002
1	CollagenIBA 01/2022
1	endolysinIBA 01/2022
1	Oncostatin MIBA 01/2021
1	Coat Protein Complex I (COPI)IBA 01/2021
1	cytochrome b245IBA 01/2021
1	DinitrofluorobenzeneIBA 01/2021
1	OxazoloneIBA 01/2021
1	Acetaminophen (Paracetamol)FDA LinkGeneric 11/2020
1	Particulate MatterIBA 11/2020
1	Notch4 ReceptorIBA 11/2020
1	Environmental Pollutants (Pollutants, Environmental)IBA 11/2020
1	Inositol (Myoinositol)IBA 01/2020

Therapy/Procedure

8	Therapeutics 11/2020 - 04/2003
4	Hematopoietic Stem Cell Transplantation 01/2020 - 12/2008
2	Cell Transplantation 07/2019 - 12/2010